YOUR HEALTH: Print your own bones

TUCSON, Arizona – People who suffer catastrophic breaks to their long leg bones usually face multiple surgeries, and all too often, amputation.

Yudith Burreal broke her leg when an ATV rolled on her a year ago.

"It was completely missing," she recalled.   "They didn't know, it was a big chunk of my bone.  It was my Tibia bone."

Her doctors used her bone and marrow to fix the break.

But Yudith ended her plans to go into the military, believing her leg wouldn't support her in training.

Scientists at the University of Arizona have been working for more than 20 years to improve the treatment protocol.

University of Arizona researchers are developing a way to fix broken long bones with stem cells, a 3-D printed scaffold, and a sensor to monitor exercise that helps bones heal.

"If we can fill our scaffold with these cells, the bone will start to form throughout the length of the scaffold," explained Dr. John Szivek, Professor, orthopaedic surgeon and head of orthopedic research, Director at the University's Robert G. Volz Orthopedic Research Laboratory.

Stem cells are multiplied in a lab and run with calcium particles through the scaffold between the bone ends.

A rod holds it in place for six to nine months.

"The scaffold is just a template," said Dr. Szivek.   "That template will help that new bone form in the right shape and structure."

"Lately, we have been successful with removing all of the supporting hardware and showing that supporting the bone that we're regrowing is actually functional tissue, to show that it does not need any additional orthopedic hardware in order to function," added Dr. David Margolis, assistant professor of orthopedic surgery at the University of Arizona.

This work is funded by a $2 million grant from the Defense Department.

"We believe that using this type of approach could regrow the bones for the soldiers and they would be able to return to active military service," said Dr. Szivek.

Researchers will report the recent success they've had with procedures on sheep to the FDA.

If the agency accepts it, a phase one trial of fewer than ten people could start soon at Banner-University Medical Center in Phoenix.

If this story has impacted your life or prompted you or someone you know to seek or change treatments, please let us know by contacting Jim Mertens at jim.mertens@wqad.com or Marjorie Bekaert Thomas at mthomas@ivanhoe.com.

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